Glossary of terms used on this site

There are 138 entries in this glossary.
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Term Definition
Activated partial thromboplastin time

A blood test that measures the time (in seconds) that it takes for clotting to occur when certain substances are added to the liquid portion of blood in a test tube. It is used to detect clotting factor deficiencies and to monitor heparin’s effe...

Adenocarcinoma

A malignant tumor formed from glandular structures in epithelial tissue.

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Aetiology

the cause of a disease

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Allele

One of two or more alternative forms of a gene that arise by mutation and are found at the same place on a chromosome

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Anticoagulant

Having the effect of inhibiting blood clotting

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Antiphospholipid syndrome

is a disorder of coagulation that causes blood clots (thrombosis) in both arteries and veins as well as pregnancy-related complications such as miscarriage, stillbirth, preterm delivery, or preeclampsia

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Antiretroviral therapy

medication for the treatment of infection by retroviruses, primarily HIV

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Antithrombin

Antithrombin (AT) is a 58 kDa (432 amino acid) single-chain glycoprotein produced in the liver. It is a member of the serpin family and is considered to be the most important inhibitor in the coagulation cascade. The healthy antithrombin concentra...

Antithrombin–heparin–factor IIa

Control of thrombin activity is crucial for the maintenance of haemostasis and the serpin antithrombin (AT) is the primary inhibitor of the blood coagulation proteases including thrombin. AT circulates at a high concentration (2.3 μM) but reacts ...

Apoptosis

A natural process of self-destruction in certain cells that is determined by the genes and can be initiated by a stimulus or by removal of a repressor agent. Also called programmed cell death.

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Apple domain

Found in tandem repeats of about 90 amino acids, the apple domain has six conserved cysteines arranged in three disulfide bonds: first to sixth, second to fifth, and third to fourth cysteines. The domain is aptly named for the two-dimensional repr...

Arterial

Of or relating to an artery or arteries (i.e. relating to any of the muscular-walled tubes that carry oxygenated blood from the heart to all parts of the body).

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Asymptomatic

absence of symptoms

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Atherosclerosis

A disease of the arteries characterized by the deposition of plaques of fatty material on their inner walls

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Cardiovascular

of or relating to the heart and blood vessels

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