Glossary of terms used on this site

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Term Definition
Paget-Schroetter disease

Upper extremity deep vein thrombosis (UEDVT) in which blood clots form in the deep veins of the arms. These deep vein thromboses typically occur in the axillary vein or subclavian vein.

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Pathophysiological

associated with or resulting from disease or injury.

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Peripheral artery disease

narrowing of one or more arteries in the extremities, usually the legs.

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Plasminogen

Plasminogen is an 88 kDa (790 amino acid) single-chain glycoprotein zymogen which is synthesised in the liver and circulates (half-life about 2 days) in plasma at a concentration of approximately 2.4 μM (200 μg/mL). This form (full length) is ca...

Plasminogen activator inhibitor type 1

Is a serine protein inhibitor that inhibits fibrinolysis. 

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Pro-inflammatory

tending to cause inflammation

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Procoagulant

relating to substances that promote reactions that ultimately result in the conversion in the blood of the inactive protein prothrombin to the clotting enzyme thrombin.

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Prognosis

the likely course of a disease or ailment

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Prolactin

A hormone released from the anterior pituitary gland that stimulates milk production after childbirth.

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Prophylaxis

action taken to prevent disease.

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Prostatectomy

Surgery to remove all or part of the prostate gland

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Protein C

Protein C is a 62 kDa vitamin-K-dependent zymogen that is synthesised in the liver as a single-chain polypeptide and is converted to a disulfide-linked heterodimer before secretion into the plasma. In the plasma, protein C circulates at 65 nM (4 Î...

Protein C deficiency

Protein C is one of the major inhibitors of the coagulation system. Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease.

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Protein C inhibitor

Protein C inhibitor (PCI) is a 57 kDa (387 amino acid) serpin that is produced in the liver and secreted into the plasma at a concentration of around 90 nM (5 μg/mL) with a half-life of about 1 day. PCI inhibits activated protein C (APC) as well ...

Protein S deficiency

Protein S is a nonenzymatic cofactor of protein C. Protein S deficiency is a rare genetic trait that prediposes to thrombotic disease.

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