thrombin-activable fibrinolysis inhibitor is an enzyme tha plays a role in fibrinolysis. 

Tissue factor pathway inhibitor is a protein that inhibits coagulation.

A sedative and hypnotic drug that inhibits angiogenesis. It was marketed in the 1960s as Softenon®, and prescribed to pregnant women, causing a large number of newborns with malformations of the limbs.

During coagulation thrombin enhances its own production by activating both cofactors factor V and factor VIII. When thrombin is bound to thrombomodulin (TM) the substrate specificity is altered such that it now prefers to activate the zymogen prot...

Thrombomodulin (TM) is a single-chain, integral membrane protein (≈100 kDa) constitutively expressed on the surface of vascular endothelial cells. TM has roles in coagulation, inflammation, fibrinolysis and cellular proliferation.

In coa...

Propensity to develop thrombosis due to a genetic or chronic abnormality in the system of coagulation. 

Obstructive clotting of the blood.

Human tissue factor (TF) is an integral membrane protein consisting of a 219 amino acid extracellular domain, a single membrane-spanning domain (22 amino acids) and a short cytoplasmic tail (21 amino acids). The extracellular domain has been expre...

Tissue factor pathway inhibitor (or as it is better known TFPI) is a single-chain polypeptide (≈40 kDa) composed of three Kunitz domains and a heparin–cell binding domain. It is constitutively expressed by endothelial cells between 1 and 4 nM ...

The cofactor for the serine protease factor VIIa is tissue factor (TF). In 1996, Banner and his colleagues solved the crystal structure of active-site-inhibited human factor VIIa bound to a protease-cleaved form of human soluble TF. This structure...

Tissue plasminogen activator (t-PA) is a 70 kDa (527 amino acid) serine protease predominantly found on the surface of endothelial cells of veins and capillaries. t-PA is secreted after vascular injury; thus in a healthy individual very low plasma...

Lasting only for a short time; impermanent.